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https://geneticliteracyproject.org/2018/11/05/why-you-need-to-know-about-rna-therapy-and-its-potential-to-revolutionize-disease-treatment/Se studiaza chestia asta de vreo 3 decenii.Problema e ca atunci când lucrezi pe genele clientului, poti sa-l "programezi" inclusiv când vrei sa-i stingi lumina.[...]
[...]A 2011 study reviewed a decade worth of drug approvals found that of 75 drugs that worked in a completely new way, 28 came from the more old-fashioned method of screening drugs against cells or animals, and 17 were built from detailed understanding of how the disease worked. David Swinney of the Institute for Rare and Neglected Diseases Drug Discovery said that despite the fact that far more resources are devoted to developing drugs by focusing on targets, the older method of screening has been more productive by his analysis.[...]That’s what drives Thomas Bernhardt, a Harvard Medical School scientist who last year published a paper in Cell showing how penicillin, the wonder drug of more than a half century ago, works. The traditional understanding has been that the drug interfered with bacteria's cell wall, causing the germs to burst. But Bernhardt found that in fact, the drug also puts the bacteria into a futile cycle of building and tearing down cell wall components that it can't use -- he compares it to throwing a wrench in an engine.[...]Robert Raffa, a professor of pharmacology at Temple University School of Pharmacy, has spent time trying to figure out how a drug found in most people’s bathroom cabinets works: the medical mystery of Tylenol.“We can eliminate things. It is not obviously morphine-like, it is not obviously aspirin-like, and it seems so we’re beginning to narrow it down," Raffa said. "Here’s why it’s very, very important: It’s because the other options for pain relief are not optimal, by a long shot."Drug discovery does sometimes follow that neat progression, but even when a drug starts with a coherent scientific idea about what the drug is supposed to do, twists in the road can seem like the norm. Erectile dysfunction drugs had their origins in the side effects of a blood pressure drug. Thalidomide was infamously used for morning sickness before being pulled from the market and then rescued to be used as a drug in cancer and leprosy.
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Subiect: Despre Coronavirus (Citit de 164057 ori)
